Green tea may protect against telomere shortening due to biological aging

Studies have reported that telomeres consisting of repeated DNA sequences (TTAGGG) play an essential role in protecting the human chromosome ends from fusions and degradation. Replication of cells causes shortening of the telomeres due to the end replication problem causing cellular senescence. Recent studies measured leukocyte telomere length (LTL) as a biological aging marker and showed an inverse relationship between chronological age and LTL. However, few studies have reported the association of LTL with hypertension, obesity, cardiovascular diseases, cancer, dementia, and diabetes mellitus.

Research has highlighted that genetic and lifestyle factors, including alcohol consumption and diet, can influence LTL. A few studies have also indicated the association of LTL with the consumption of beverages such as coffee, tea, and sweetened beverages. However, most of them were analyzed in cross-sectional data since longitudinal data were limited. For example, only one study reported longitudinal changes in LTL due to green tea consumption in obese women. Several previous studies have indicated significant mortality with coffee and green tea consumption and changes in LTL. Therefore, it is vital to understand the association between LTL changes and these beverages concerning lifestyle factors related to longevity.

A new study in Scientific Reports aimed to analyze the association between cross-section and longitudinal LTL changes with the consumption of soft drinks, coffee, and tea among middle-aged and older Korean men and women for six years. It also assessed any changes in the association results according to a difference in sex and age groups.

Study: Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length. Image Credit: Kirasolly/Shutterstock

About the study

The study involved recruiting 5,012 participants between June 2001 and January 2003 who were followed up since February 2003. A comprehensive health examination involving bio-specimen collection, blood pressure (BP) measurement, and anthropometric assessment, along with a questionnaire-based interview, was carried out at baseline. In addition, information about the participant’s medical history, demographics, lifestyle, including smoking and alcohol drinking, health conditions, and dietary intake, was collected through the questionnaire.

The initial investigation occurred between February 2011 and November 2012 (baseline), while repeated measurements occurred between February 2017 and December 2018 (follow-up). At baseline, information on coffee, green tea, and soft drink consumption was collected using a caffeine food frequency questionnaire (C-FFQ). Next, measurement of relative LTL took place using quantitative real-time polymerase chain reaction. Finally, potential confounding variables, including physical activity, alcohol consumption status, smoking status, presence of diabetes mellitus or hypertension, income status, body mass index (BMI), age, and sex, were considered.

study findings

The results indicated that 1,952 participants were included in the study. The baseline values ​​of LTL shortening were reported to be more significant compared to follow-up values. Participants with more LTL shortening were observed to be mostly males, current smokers, and those who consumed less green tea. Participants who consumed green tea were observed to have less LTL shortening for both cross-sectional and longitudinal associations. No significant observations were reported for the other beverages. This association of green tea consumption was observed to be more significant for participants younger than 65.

Therefore, the current study demonstrates that the consumption of green tea can be beneficial against LTL shortening, which might impact biological aging. However, further studies with participants of different ethnicities and ages are required to confirm such findings.

Telomeres are protective caps on the ends of chromosomes.  Image Credit: Fancy Tapis / ShutterstockTelomeres are protective caps on the ends of chromosomes. Image Credit: Fancy Tapis / Shutterstock


The study has certain limitations. First, the assessment of telomeres took place in leukocytes rather than in somatic cells. Second, follow-up information on beverage consumption is unavailable, which might lead to weak or null associations. Third, the study did not include unadjusted confounding factors such as diet and dietary supplements.


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